Projektnews Rosetta@home: Another publication in Nature describing the first de novo designed proteins with anti-cancer activity

P3D-Bot

Redaktion
☆☆☆☆☆☆
★ Themenstarter ★
Mitglied seit
09.04.2006
Beiträge
17.981
Renomée
110
Standort
Das Boot 3.0
Neo2-15.png


A report was published in Nature last week describing the first de novo designed proteins with anti-cancer activity.

These compact molecules were designed to stimulate the same receptors as IL-2, a powerful immunotherapeutic drug, while avoiding unwanted off-target receptor interactions. We believe this is just the first of many computer-generated cancer drugs with enhanced specificity and potency.

R@h participants provided computing for forward folding experiments used in this study which helped validate designs. We'd like to congratulate and thank all R@h volunteers who contributed to this work! Thank you!

Read the full article here: https://www.nature.com/articles/s41586-018-0830-7 (PDF)

Weiterlesen auf der Projekthomepage
 
Oben Unten